Look Who's at the Lab: Hiyam Hamaed (July 2009)
In Look Who's at the Lab, we profile some of the hundreds of scientists who visit our lab every year.
Hiyam Hamaed.
Title: Graduate student, University of Windsor
Mag Lab user since: 2007
Number of visits to the lab: 2
Dates of most recent experiment:
July 27-31, 2009
Distance traveled: 993 miles / 1,598 km (Windsor, Ontario to Tallahassee, Florida)
Research Interests:
"I work under the supervision of Dr. Robert W. Schurko. Our research interests focus upon the application of solid-state NMR to the study of a wide variety of materials ranging from pharmaceuticals, inorganic materials (i.e., nanoparticles, mesoporous, host-guest) and organometallic complexes. We are also interested in development and application of special NMR pulse programs to open up most of the periodic table (i.e., unreceptive nuclei) to routine investigation via solid-state NMR spectroscopy."
Web site: http://mutuslab.cs.uwindsor.ca/schurko/
Email: hamaed@uwindsor.ca
Title: 35Cl static and MAS NMR experiments of hydrochloride pharmaceutical drugs
Other Participants: Riqiang Fu of the Mag Lab; Robert W. Schurko and Mike Laschuk of the University of Windsor
Synopsis: "Polymorphs, which are distinct, stable phases of a pure substance resulting from a minimum of two different arrangements of the molecules or atoms in the solid state, are of great interest in many areas of chemistry. Most active pharmaceutical ingredients can adopt more than one polymorphic phase. Identification of different polymorphs is of great importance in the pharmaceutical industry and associated laboratories, since (i) ca. 80% of solid pharmaceuticals possess more than one polymorphic form, and (ii) different polymorphs can have distinct physicochemical properties which can affect their performance. Hydrochloride drugs constitute more than 50% of pharmaceutical salts, and chlorine is present in ca. 25% of drugs, most of which are known to exhibit polymorphs. 35Cl solid-state NMR is a very useful probe for structural characterization of a variety of Cl-containing drugs and the identification of different polymorphs. In addition, the use of ultrahigh field NMR spectrometers is very crucial for the success of this research, for fast acquisition of high-quality NMR spectra, accurate determination of NMR parameters, and correlation of these parameters to the solid-state drug structures."
Facility: NMR Facility, Tallahassee
Equipment: Ultra-wide bore 900 MHz magnet
Techniques: 35Cl solid-state NMR (magic-angle spinning NMR, static NMR, Hahn echoes, quadrupolar CPMG pulse sequence)
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Favorite thing about working at the lab:
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I have many favorite things about the lab. The facility has a great atmosphere for getting work done in an enjoyable way, and the staff are excellent in both their support and help. I had a very pleasant time being around such bright people. |
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Thing you miss most about home when you're here:
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Going to gym.
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Your proudest science moment:
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I will live this moment once I have handed in my Ph.D. thesis.
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What keeps you awake at night:
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An experiment that did not work.
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The most unscientific thing about you:
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To be honest, being very interested in fashion.
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Your hero:
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My hero is anyone who has a strong faith in him/her self and patiently and successfully accomplishes his/her goals without ever giving up. |
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Last book you read:
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The God Delusion, by Richard Dawkins. |
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Parting thoughts on science today:
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"The joy of discovery is certainly the liveliest that the mind of man can ever feel." (Claude Bernard). There are many things that are waiting to be discovered for the sake of having a better life on our Earth, ranging from curing cancer, to finding better ways for generating energy and providing a long-lasting, cleaner environment. All these require the collaboration of scientists from all disciplines to come up with better solutions to problems encountered in our everyday lives. |
- H. Hamaed, M.W. Laschuk, V.V. Terskikh and R.W. Schurko, 2009. Application of Solid-State 209Bi NMR to the Structural Characterization of Bismuth-Containing Materials. J. Am. Chem. Soc. 131, 8271-8279
- H. Hamaed, A.Y.H. Lo, L.J. May, J.M. Taylor, G.H. Shimizu and R.W. Schurko, 2008. Investigation of Silver-Containing Layered Materials and Their Interactions with Primary Amines using Solid-State 109Ag and 15N NMR Spectroscopy and First Principles Calculations. Inorg. Chem. 47, 11245-11256.
- H. Hamaed, J.M. Pawlowski, B.F.T. Cooper, R. Fu, S.H. Eichhorn and R.W. Schurko, 2008. Application of Solid-State 35Cl NMR to the Structural Characterization of Hydrochloride Pharmaceuticals and their Polymorphs. J. Am. Chem. Soc. 130, 11056-11065.
- H. Hamaed, A.Y.H. Lo, D.S. Lee, W.J. Evans and R.W. Schurko, 2006. Solid-State 139La and 15N NMR Spectroscopy of Lanthanum-Containing Metallocenes. J. Am. Chem. Soc. 128, 12638-12639.
Date posted: July 2009
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