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James R. Rocca

Senior Chemist
UF, AMRIS Affiliated Faculty & Staff

Phone: 352 - 294-0126
Fax: 352 - 392-3422
Address: McKnight Brain Institute
1149 South Newell Dr., P.O. Box 100015
Gainesville , FL 32611-

Disclaimer: The information presented below was automatically generated from a database. In the rare instance of an exact name match, it is possible that a citation is inaccurately attributed. The listing should therefore be considered unofficial. To report a mismatched publication, contact IMsystems@magnet.fsu.edu.

Publications and Scientific Activities

##Peer-Reviewed Publications
1 Borrero, N.V.; Bai, F.; Perez,C.; Duong, B.Q.; Rocca, J.R.; Jin, S. and Huigens, R.W., Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis, Organic & Biomolecular Chemistry, 12 (6), 881-886 (2014) [read online]
2 Carter, J.D.; Gonzales, E.G.; Huang, X.; Smith, A.N.; de Vera, I.M.S.; D'Amore, P.W.; Rocca, J.R.; Goodenow, M.M.; Dunn, D.M. and Fanucci, G.E., Effects of PRE and POST therapy drug-pressure selected mutations on HIV-1 protease conformational sampling, Febs Letters, 588 (17), 3123-3128 (2014) [read online]
3 Huang, X.; Britto, M.D.; Kear-Scott, J.L.; Boone, C.D.; Rocca, J.R.; Simmerling, C.; McKenna, R.; Bieri, M.; Gooley, P.R.; Dunn, B.M. and Fanucci, G.E., The Role of Select Subtype Polymorphisms on HIV-1 Protease Conformational Sampling and Dynamics, J. Biol. Chem., 289 (24), 17203-17214 (2014)
4 Huang, X.; de Vera, I.M.; Veloro, A.M.; Rocca, J.R.; Simmerling, C.; Dunn, B.M. and Fanucci, G.E., Backbone ¹H, ¹³C, and ¹⁵N chemical shift assignment for HIV-1 protease subtypes and multi-drug resistant variant MDR 769., Biomol NMR Assing, 7 (2), 199-202 (2013) [read online]
5 Huang, X.; de Vera, I.M.S.; Veloro, A.M.; Rocca, J.R.; Simmerling, C.; Dunn, B.M. and Fanucci, G.E., Backbone H-1, C-13, and N-15 chemical shift assignment for HIV-1 protease subtypes and multi-drug resistant variant MDR 769, Biomolecular NMR Assignments, 7 (2), 199-202 (2013) [read online]
6 Singh, S.; Dirain, M.; Witek, R.; Rocca, J.R.; Edison, A.S. and Haskell-Luevano, C., Structure−Activity Relationships of Peptides Incorporating aBioactive Reverse-Turn Heterocycle at the Melanocortin Receptors:Identification of a 5800-fold Mouse Melanocortin‑3 Receptor(mMC3R) Selective Antagonist/Partial Agonist versus the MouseMelanocortin‑4 Receptor (mMC4R), Medicinal Cemistry, 56, 2747-2763 (2013) [read online]
7 Clark, V.C.; Harinantenaina, L.; Zeller, M.; Ronto, W.; Rocca, J.; Dossey, A.T.; Rakotondravony, D.; Kingston, D.G.I. and Shaw, C., An Endogenous Bile Acid and Dietary Sucrose from Skin Secretions of Alkaloid-Sequestering Poison Frogs, J. of Natural Products, 75 (3), 473-478 (2012) [read online]
8 Huang, X.; de Vera, I.M.S.; Veloro, A.M.; Blackburn, M.E.; Kear, J.L.; Carter, J.D.; Rocca, J.R.; Simmerling, C.; Dunn, B.M. and Fanucci, G.E., Inhibitor-Induced Conformational Shifts and Ligand-Exchange Dynamics for HIV-1 Protease Measured by Pulsed EPR and NMR Spectroscopy, J. Phys. Chem. B, 116 (49), 14235-14244 (2012) [read online]
9 Huang, X.; de Vera, I.M.S.; Veloro, A.M.; Rocca, J.R.; Simmerling, C.; Dunn, B.M. and Fanucci, G.E., Backbone 1H, 13C, and 15N chemical shift assignment for HIV-1 protease subtypes and multi-drug resistant variant MDR 769, Biomol. NMR Assign., Online, 21 June (2012) [read online]
10 Waller, J.C.; Ellens, K.W.; Hasnain, G.; Alvarez, S.; Rocca, J.R. and Hanson, A.D., Evidence that the Folate-Dependent Proteins YgfZ and MnmEG Have Opposing Effects on Growth and on Activity of the Iron-Sulfur Enzyme MiaB, J. Bacteriology, 194 (2), 362-367 (2012) [read online]
11 Huffaker, A.; Kaplan, F.; Vaughan, M.M.; Dafoe, N.J.; Ni, X.Z.; Rocca, J.R.; Alborn, H.T.; Teal, P.E.A. and Schmelz, E.A., Novel Acidic Sesquiterpenoids Constitute a Dominant Class of Pathogen-Induced Phytoalexins in Maize, Plant Physiology, 156 (4), 2082-2097 (2011)
12 Schmelz, E.A.; Kaplan, F.; Huffaker, A.; Dafoe, N.J.; Vaughan, M.M.; Ni, X.; Rocca, J.R.; Alborn, H.T. and Teal, P.E., Identity, regulation, and activity of inducible diterpenoid phytoalexins in maize, P. Natl. Acad. Sci. U.S.A., 108 (13), 5455-5460 (2011)
13 Waller, J.C.; Alvarez, S.; Naponelli, V.; Lara-Nuñez, A.; Blaby, I.K.; Da Silva, V.; Ziemak, M.J.; Vickers, R.J.; Beverley, S.M.; Edison, A.S.; Rocca, J.R.; Gregory, J.F. 3rd; de Crécy-Lagard, V. and Hanson, A.D., A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life, P. Natl. Acad. Sci. U.S.A., 107 (23), 10412-7 (2010)
14 Kem, W.R.; Rocca, J.; Garraffo, H.M.; Spande, T.F.; Daly, J.W. and Soti, F., Synthesis and spectroscopic comparison of the eight methyl-2,3' -bipyridyd, Heterocycles, 79, 1025-1041 (2009)
15 Tarver, M.R.; Schmeiz, E.A.; Rocca, J.R. and Scharf, M.E, Effects of Soldier-Derived Terpenes on Soldier Caste Differentiation in the Termite Reticulitermes flavipes, J. Chem. Ecol., 35 (2), 256-264 (2009)
16 Kwan, J.C.; Rocca, J.R.; Abboud, K.A.; Paul, V.J. and Luesch, H., Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin, Organic Letters, 10, 789-792 (2008)
17 Bergeron, R.J.; Wiegand, J.; Bharti, N.; Singh, S. and Rocca, J.R., Impact of the 3,6,9-trioxadecyloxy group on desazadesferrithiocin analogue iron clearance and organ distribution, J. Med. Chem., 50 (14), 3302-3313 (2007)
18 Coowanitwong , I.; Arya, V.; Patel, G.; Kim, W.S.; Craciun, V.; Rocca, J.R.; Singh, R. and Hochhaus, G., Laser-ablated nanofunctional polymers for the formulation of slow-release powders for dry powder inhalers: physicochemical characterization and slow-release characteristics, J. Pharm. Pharmacol., 59 (11), 1473-84 (2007)
19 Mathew, S.(Susan); Ross, C.; Rocca, J.R.; Paul, V.J. and Luesch, H., Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides, J. Natural Products, 70 (1), 124-127 (2007)
20 Taori, K.; Matthew, S.; Rocca, J.R.; Paul, V.J. and Luesch, H., Lyngbyatatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya SPP, J. Natural Products, 70 (10), 1593-1600 (2007)
21 Bergeron, R.J.; Wiegand, J.; McManis, J.S.; Vinson, J.R.T.; Yao, H.; Bharti, N. and Rocca, J.R., (S) -4, 5-dihydro-2-( 2-hydroxy-4-hydroxyphenyl) -4-methyl-4-thiazolecarboxylic acid polyethers: A solution to nephrtoxicity, J. Med. Chem., 49 (9), 2772-2783 (2006)
22 Brey, W.W.; Edison, A.S.; Nast, R.; Rocca, J.; Saikat Saha, S. and Withers, R.S., Design, Construction and Validation of a 1 mm Triple Resonance High-Temperature Superconducting Probe for NMR, J. Magn. Reson., 179 (2), 290-293 (2006) [read online]
23 Dossey, A.T.; Walse, S.S.; Rocca, J.R. and Edison, A.S., Single Insect NMR: A New Tool to Probe Chemical Biodiversity, ACS Chemical Biology, 1 (8), 511-514 (2006)
24 Quint, P.S.; Ayala, I.; Busby, S.A.; Chalmers, M.J.; Griffin, P.R.; Rocca, J.; Nick, H.S. and Silverman, D.N., Structural mobility in human manganese superoxide dismutase, Biochemistry, 45, 8209-8215 (2006)
25 Beck, B.L.; Jenkins, K.A.; Rocca, J.R. and Fitzsimmons J.R., Tissue-Equivalent Phantoms for High Frequencies, Concepts in Magnetic Resonance Part B (Engineering), 20B (1), 30-33 (2004) [read online]
26 Beck, B.L.; Jenkins, K.A.; Rocca, J.R.; Kim H. and Fitzsimmons, J.R, Tissue Equivalent Phantoms at 470 MHz, Int. Soc. Mag. Reson. Med., Toronto, 2364 (2003)
27 Smith, L.; Zachariah, C.; Thirumoorthy, R.; Rocca, J.; Novak, J.; Hillman, J.D. and Edison, A.S., Structure and Dynamics of the Lantibiotic Mutacin 1140, Biochemistry, 42 (35), 10372-10384 (2003) [read online]
28 Prokai, L.; Prokai-Tatrai, K.; Zharikova, A.; Li, X. and Rocca, J.R., Combinatorial Lead Optimization of a Neuropeptide FF Antagonist, J. Med. Chem., 44, 1623-1626 (2001)
29 Smith, L.; Novak, J.; Rocca, J.; McClung, S.; Hillman, J. and Edison, A., Covalent Structure of Mutacin 1140 and a Novel Method for the Rapid Identification of Lantibiotics, Eur. J. Biochem., 267, 6810-6816 (2000)

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