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Nicolas L. Young

Research Faculty I
CIMAR, ICR

Email:
Phone: 850 - 644-0648
Fax: 850 - 644-1366
Address: NHMFL FSU
1800 E. Paul Dirac Dr.
Tallahassee , FL 32310-3706

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Educational Background:
Postdoctoral Fellowship, Molecular Biology Princeton University
Advisor: Benjamin A. Garcia (Feb 2008-Mar 2012)
Ph.D., Chemistry (March 2007) University of California, Davis
Advisor: Carlito B. Lebrilla
B.S., Chemistry (May 1999) University of California, Berkeley

Research Interests:
Chromatin and Epigenetics

My research integrates molecular biology and bioanalytical chemistry as well as elements of genomics, systems biology and computational approaches. These are combined in a unified cross-disciplinary effort to elucidate the role of protein post-translational modifications in the decision-making and information storage mechanisms of eukaryotic biology. This emerging area of research is commonly described as epigenetics and chromatin regulation. This core but relatively unstudied biological functionality is essential to multiple areas including transcription regulation, stem cell biology, regenerative medicine, cancer biology, disease diagnostics & therapeutics, developmental biology and fundamental cellular physiology.

Bioanalytical Mass Spectrometry

The central tool that enables all of my research is bioanalytical mass spectrometry. As Director of Biology for the Ion Cyclotron Mass Spectrometry program I have the privilege of directing a variety of efforts using the most powerful bioanalytical mass spectrometers ever created. This involves the development of novel chromatographic, mass spectrometric, and bioinformatic approaches to address biological questions with unprecedented specificity.

Professional Experience:
Director of Biological Applications, Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University (2012-present)

Postdoctoral Research Fellow, Advisor: Benjamin A. Garcia, Molecular Biology Department, Princeton University (2008-2012)

Doctoral Studies, Advisor: Carlito B. Lebrilla, Department of Chemistry, University of California, Davis (2002-2007)

Staff Scientist, Biosecurity and Nanoscience Laboratory, Lawrence Livermore National Laboratory, Livermore, CA (2002-2008)

Mass Spectrometrist, Bay Bioanalytical Laboratory, Hercules, CA (1999-2002)



Disclaimer: The information presented below was automatically generated from a database. In the rare instance of an exact name match, it is possible that a citation is inaccurately attributed. The listing should therefore be considered unofficial. To report a mismatched publication, contact IMsystems@magnet.fsu.edu.


Publications and Scientific Activities

##Peer-Reviewed Publications
1 Zhang, Q.; Chen, J.; Kuwajima, K.; Zhang, H.-M.; Xian, F.; Young, N.L. and Marshall, A.G., Nucleotide-Induced Conformational Changes of Tetradecameric GroEL Mapped by Hydrogen/Deuterium Exchange Monitored by Ultrahigh Resolution FT-ICR Mass Spectrometry, Scientific Reports, 3, 1247 (2013)
2 Zhang, Q.; Noble, K.A.; Mao, Y.; Young, N.L.; Roux, K.H. and Marshall, A.G, Rapid Screening for Potential Epitopes Reactive with a Polycolonal Antibody by Solution-Phase Amide Backbone H/D Exchange Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, J. Am. Soc. Mass Spectr., 24, 1016-1025 (2013)
##Presentations, Posters & Abstracts
1 Dang, X.; Scotcher, J.; Tao, Y.; Marshall, A.G. and Young, N.L., Top-Down Analysis of Histone Post-Translational Modifications by Electron Capture Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, 2013 ASMS Sanibel Conference: Top-Down Mass Spectrometry, St. Pete Beach, FL, January 24-27 (2013)
2 Dang, X.; Scotcher, J.; Tao, Y.; Marshall, A.G. and Young, N.L., Top-Down Analysis of Core Histone Post-Translational Modifications by Electron Capture Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, 9th N. American Fourier Transform Mass Spectrometry Conf., Key West, FL, April 28-May 1 (2013)
3 Dang, X.; Scotcher, J.; Tao, Y.; Sasaki, T.; Gilbert, D.M.; Marshall, A.G. and Young, N.L., Dynamic Changes in Histone Post-Translational Modifications During the Cell Cycle by Top-Down MS/MS Analysis, 61st Amer. Soc. Mass Spectrometry Conf., Minneapolis, MN, June 9-13 (2013)
4 Dang, X.; Tao, Y.; Sasaki, T.; Marshall, A.G.; Gilbert, D. and Young, N.L., Histone ‘Proteoforms’ Before and After Replication, Eukaryotic DNA Replication and Genome Maintenance, Cold Spring Harbor, NY, 9-13 Sept (2013)
5 Feng, S.; Ding, S.-J.; Dodmane, P.R.; Scotcher, J.; Arnold, L.L.; Young, N.L.; Marshall, A.G. and Cohen, S.M., Identification of the Interaction of Trivalent Arsenicals with Metallothionein by Use of Ultrahigh Resolution Mass Spectrometry, 61st Amer. Soc. Mass Spectrometry Conf., Minneapolis, MN, June 9-13 (2013)
6 He, H.; Rodgers, R.P.; Young, N.L. and Marshall, A.G., Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry Characterization of Nannochloropsis Oculata, a Green Algae, 245th Amer. Chem. Soc. Natl. Mtg., New Orleans, LA, April 7-11 (2013)
7 He, H.; Young, N.L. and Marshall, A.G., Identification of Nuclear Lipids, 61st Amer. Soc. Mass Spectrometry Conf., Minneapolis, MN, June 9-13 (2013)
8 Liu, H.; Nilsson, K.B.; Shavkunov, A.; He, H.; Gwak, Y.S.; Hassler, S.N.; Johnson, K.M.; Wildburger, N.C.; Young, N.L.; Marshall, A.G.; Huisebosch, C.E. and Nilsson, C.L., MALDI Imaging and FT-ICR MS Mapping of Lipid Alterations in Spinal Cord Injury, 61st Amer. Soc. Mass Spectrometry Conf., Minneapolis, MN, June 9-13 (2013)
9 Mao, Y.; Young, N.L.; Hendrickson, C.L. and Marshall, A.G., Ultrahigh Mass Accuracy and Mass Resolution FT-ICR MS: Identification of All Possible CcHhNnOoSs13Ccc34Sss Compositions in Complex Mixtures, 61st Amer. Soc. Mass Spectrometry Conf., Minneapolis, MN, June 9-13 (2013)
10 Marshall, A.G.; Scotcher, J. and Young, N.L, Determination of Site-Specific Protein Disulfide Bond Reduction Potentials by Top-Down FT-ICR MS/MS, 61st Amer. Soc. Mass Spectrometry Conf., Minneapolis, MN, June 9-13 (2013)
11 Marshall, A.G.; Scotcher, J. and Young, N.L., Determination of Site-Specific Protein Disulfide Bond Reduction Potentials by Top-Down FT-ICR MS/MS, 2013 ASMS Sanibel Conf.: Top-Down Mass Spectrometry, St. Pete Beach, FL, January 24-27 (2013)
12 Marshall, A.G.; Zhang, H.-M.; Zhang, Q. and Young, N.L., Understanding Drug Action and Drug Resistance from their Effects on Protein Receptor Structure, Biomedical Sciences Symposium: Modeling Human Disease, Florida State University, Tallahassee, FL, February 14-15 (2013)
13 Marshall, A.G.; Zhang, Q.; Zhang, H.-M. and Young, N.L., Understanding Drug Action and Drug Resistance from Their Effects on Protein Receptor Structure, Tenth Annual Southeast Regional Consortium Access Team (SERCAT) Mtg and Structural Biology Symp, Tallahassee, FL, March 15 (2013)
14 Nilsson, C.L.; Nilsson, K.B.; He, H.; Liu, H.; Shavkunov, A.; Gwak, Y.S.; Hassler, S.N.; Johnson, K.M.; Young, N.L.; Marshall, A.G. and Hulsebosch, C.E., Novel Glycolipid Markers of Chronic Pain Following Spinal Cord Injury, Neuroscience 2013, San Diego, CA, 9-13 November (2013)
15 Nilsson, K.B.; He, H.; Gwak, Y.S.; Hassler, S.N.; Johnson, K.M.; Helsbosch, C.E.; Liu, H.; Shavkunov, A.; Wildburger, N.C.; Young, N.L.; Marshall, A.G. and Nilsson, C.L., Glycolipid Changes in Spinal Cord Injury Determined by Mass Spectrometric Imaging and High Resolution Mass Spectrometry, 25th New Orleans Carbohydrate Symposium, New Orleans, LA, April 5-6 (2013)
16 Tao, Y.; Khorasanizadeh, S.; Zhang, Q.; Rastinejad, F.; Marshall, A.G. and Young, N.L., Probing Conformational Dynamics of Nuclear Receptor Co-Activator PGC-1α by H/D Exchange Coupled with FT-ICR MS, 61st Amer. Soc. Mass Spectrometry Conf., Minneapolis, MN, June 9-13 (2013)
17 Tao, Y.; Trakselis, M.; Zhang, Q.; Marshall, A.G. and Young, N.L., Identification of the Interacting Surface of Sulfolobus solfataricus Minichromosome Maintenance (SSOMCM Helicase and Single Strand DNA (SSDNA) by H/D Exchange Monitored by FT-ICR MS, 9th N. American Fourier Transform Mass Spectrometry Conf., Key West, FL, April 28-May 1 (2013)
18 Young, N.L.; Dang, X.; He, H.; Scotcher, J.; Tao, Y. and Marshall, A.G., Study of the Eukaryotic Nucleus by Use of High Resolution FT-ICR Mass Spectrometry, 9th N. American Fourier Transform Mass Spectrometry Conf., Key West, FL, April 28-May 1 (2013)
19 Zhang, Q.; Gang, P.; Young, N.L.; Guo, M. and Marshall, A.G., LysRS Novel Function with PhosphorylatedThr52 Revealed by H/D Exchange FT-ICR Mass Spectrometry, 61st Amer. Soc. Mass Spectrometry Conf., Minneapolis, MN, June 9-13 (2013)
20 Young, N.L., The Role of Combinations of Post-translational Modifications in Chromatin Biology: Direct Measurement of 'PTM Isoforms'., Florida State University Chemistry and Biochemistry Department, October 16th (2012)




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